medium lethal dose

The oral acute toxicity test showed LD50 ( medium lethal dose)> 5.5 g/ Kg. Such result demonstrates that the synthesized product is nontoxic according to the classification of acute toxicity standard.

通过对合成的产物进行急性经口毒性试验，发现其经口半数致死量（LD50，medium lethal dose）大于5.5g/Kg，按照急性毒性分级标准确定该依布硒林衍生物属实际无毒级。

Conclusion Nano-hydroxyapatite has no accumulative toxicity to rabbits, it is suggested that it is safe when the hydroxyapatite-sol was applied intravenously as a drug carrier in small dosage more less than the medium lethal dose, even as a kind of anticancer drug.

结论纳米HAP在家兔无明显蓄积毒性，提示当用量远远小于最小致死剂量时，纳米HAP可作为药物载体，甚至在将来可能作为一种新型的抗癌药物，经静脉安全应用。